[Effect of 2 mercaptopropionylglycine on the cytotoxic activity of lymphocytes from patients with chronic active hepatitis against rabbit hepatocytes isolated and cultured in vitro].

Abstract

"In vivo" and "in vitro" action of 2 MPG on lymphocytotoxic activity was evaluated in 22 patients with CAH, 14 were HBsAg positive and 8 were negative. The test was performed with and without 2 MPG in the colture medium, and before and after treatment. HBsAg+ patients received 2 MPG treatment, while HBsAg- ones received immunosoppressive therapy and 4 of these were on 2 MPG treatment as well. Cytotoxic Index was reduced non-significantly by addition of 2 MPG in colture medium in both groups. 2 MPG treatment does not modify cytotoxic activity which is reduced by immunosoppressive therapy. These findings suggest a positive effect of 2 MPG on liver-cell metabolism with an increased resistence of the epatocyte to the "in vitro" lymphocytes aggression. Hence it may be suggested an association treatment with immunosoppressive agents and 2 MPG.

• Authors: M Mazzetti, G Guizzardi, R Meliconi, M Baraldini, M V Stancari, M Mazzoli, G F Stefanini
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 57 Issue 14 Pg. 1477-83 (Jul 30 1981) ISSN: 0037-8771 [Print] Italy
• Vernacular Title: Effetto della 2 mercaptopropionilglicine (2 MPG) sull'attività citotossica contro epatociti di coniglio isolati e coltivati in vitro dei linfociti di soggetti con epatite cronicaz attiva.
• PMID: 7295410 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids, Sulfur
• Hepatitis B Surface Antigens
• Immunosuppressive Agents
• Tiopronin

Topics

• Amino Acids, Sulfur (therapeutic use)
• Animals
• Chronic Disease
• Cytotoxicity Tests, Immunologic
• Hepatitis B (drug therapy, immunology)
• Hepatitis B Surface Antigens (analysis)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Liver (drug effects)
• Rabbits
• Tiopronin (therapeutic use)