[Laboratory diagnosis of idiopathic myelofibrosis. Review of the literature and presentation of 15 cases].

Abstract

We report on 15 patients affected by myelofibrosis. The main clinical aspects were hepatosplenomegaly, anemia and leukocytosis. Immature cells and anisopoikilocytosis of the erythrocytes were frequently found in the peripheral blood. At bone biopsy, various aspects of panhyperplasia, increase in the reticular fibers, myeloid fibrosis and osteosclerosis were observed. Leukocyte alkaline phosphatase was frequently elevated. The clinical and laboratory course of the disease, causes of death and the possible etiopathogenetic aspects of this disease are considered and discussed.

• Authors: B Milanesi, F Pirali
• Journal: Minerva medica (Minerva Med) Vol. 72 Issue 34 Pg. 2265-72 (Sep 19 1981) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Diagnostica di laboratorio della mielofibrosi idiopatica. Rassegna della letteratura e presentazione di quindici casi.
• PMID: 7290453 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alkaline Phosphatase

Topics

• Adult
• Aged
• Alkaline Phosphatase (metabolism)
• Bone Marrow Examination
• Erythrocytes, Abnormal
• Female
• Humans
• Karyotyping
• Leukocytes (enzymology)
• Leukocytosis (etiology)
• Male
• Middle Aged
• Platelet Count
• Primary Myelofibrosis (blood, complications, diagnosis, etiology)