[Laboratory and clinical evaluation of cefoxitin in children (author's transl)].

Abstract

Pharmacokinetics of cefoxitin, a new injectable semisynthetic-cephamycin, was studied in 12 healthy children and also was studied cerebrospinal fluid levels in 1 patient with bacterial meningitis received 44.5 mg/kg of cefoxitin and thoracic fluid levels in 2 patients were measured. Cefoxitin was administered intravenously to 50 patients with various types of infections an average dose of 130 mg/kg/day for an average of 9 days. The results were as follows: 1. Favorable plasma levels were obtained comparing with those off conventional injectable cephalosporins after 15 mg/kg and 25 mg/kg of cefoxitin for one shot intravenous injection. The half lives of cefoxitin in the plasma were about 15.9 minutes up to 1 hour and 25.5 minutes up to 2 hours after an intravenous administration of cefoxitin at a dose of 15 mg/kg, and while, those were 15.9 minutes and 27.5 minutes after an intravenous administration of cefoxitin at a dose of 25 mg/kg, respectively. 2. Cefoxitin was excreted with high concentration up to 2 hours after the administration and thereafter, urinary concentration of cefoxitin declined rapidly with the lapse of time. The time course urinary concentration reflected those of plasma levels. Approximately 94.7% and 90.6% of dosed cefoxitin were recovered in the urine for 6 hours after the administration at the dose of 15 mg/kg and 25 mg/kg, respectively. 3. The cerebrospinal fluid levels of cefoxitin were only determined in a patient of bacterial meningitis. Therefore, further study should be performed. 4. The thoracic fluid levels with 2 patients were higher than cerebrospinal fluid levels. 5. Among the 50 patients with various infections, cefoxitin was clinically effective in 84% and bacterial response in 87%. 6. As adverse reactions, in total 79 patients included exclusive 29 patients, diarrhea occurred in 1 patient, sweating and cough in 1 patient, rash with fever in 4 patients, vascular pain in 2 patients, and leukopenia was observed in 1 patient, eosinophilia in 1 patient, and increase of GOT and LDH were observed in each 2 patients. The other adverse reactions were not experienced.

• Authors: T Motohiro, Y Sakata, T Fujimoto, T Nishiyama, T Nakajima, K Ishimoto, K Tominaga, F Yamashita, H Araki, N Takajo, S Tsugawa, K Nagayama, Y Tanaka, A Yuasa, M Koga, Y Komatsu, M Yamamoto, T Iriki, K Yoshioka, K Haraguchi, S Okada, F Imuta, M Kinoshita
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 34 Issue 3 Pg. 384-403 (Mar 1981) ISSN: 0368-2781 [Print] Japan
• PMID: 7289031 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cefoxitin

Topics

• Adolescent
• Age Factors
• Bacterial Infections (drug therapy)
• Cefoxitin (adverse effects, metabolism, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Kinetics
• Male