The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma.

Abstract

The significance of time-dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C +/- .05 C for 15 minutes, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the four fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered.

• Authors: E W Hahn, A A Alfieri, J H Kim
• Journal: Cancer (Cancer) Vol. 42 Issue 6 Pg. 2596-9 (Dec 1978) ISSN: 0008-543X [Print] United States
• PMID: 728862 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Dose-Response Relationship, Radiation
• Fibrosarcoma (therapy)
• Hyperthermia, Induced
• Male
• Mice
• Mice, Inbred BALB C
• Radiation Tolerance
• Sarcoma, Experimental (therapy)
• Time Factors