Marine animal biosynthetic constituents for cancer chemotherapy.

Abstract

A fifteen year investigation of marine animal components as sources for new and potentially useful cancer chemotherapeutic drugs has led to our discovery of a number of such valuable substance. The especially productive Indian Ocean sea hare Dolabella auricularia has yielded (100 kg leads to or approximately 1 mg each) a series of very potent cell growth inhibitory substances designated dolastatins 1-9. The first member of this new series, dolastatin 1, may represent the most potent anticancer agent so far uncovered with, e.g., a curative response (33%) using a dose of 11 microgram/kg (T/C 240, to T/C 139 at 1.37 microgram/kg) in the National Cancer Institute's murine B16 melanoma. Structural elucidation of the new antineoplastic agents is underway, and recent progress is illustrated with peptide dolastatin 3 (P388 ED 50 2.7 x 10(-7) microgram/ml).

• Authors: G R Pettit, Y Kamano, Y Fujii, C L Herald, M Inoue, P Brown, D Gust, K Kitahara, J M Schmidt, D L Doubek, C Michel
• Journal: Journal of natural products (J Nat Prod) 1981 Jul-Aug Vol. 44 Issue 4 Pg. 482-5 ISSN: 0163-3864 [Print] United States
• PMID: 7288444 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Depsipeptides
• Thiazoles
• dolastatin 1

Topics

• Animals
• Antineoplastic Agents (isolation & purification)
• Depsipeptides
• Leukemia P388 (drug therapy)
• Mice
• Mollusca (metabolism)
• Thiazoles (isolation & purification)