Abstract |
To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.
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Authors | T Wasada, K McCorkle, V Harris, K Kawai, B Howard, R H Unger |
Journal | The Journal of clinical investigation
(J Clin Invest)
Vol. 68
Issue 4
Pg. 1106-7
(Oct 1981)
ISSN: 0021-9738 [Print] United States |
PMID | 7287903
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Chylomicrons
- Gastrointestinal Hormones
- Triglycerides
- Gastric Inhibitory Polypeptide
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Topics |
- Animals
- Chylomicrons
(blood)
- Dogs
- Gastric Inhibitory Polypeptide
(pharmacology)
- Gastrointestinal Hormones
(pharmacology)
- Metabolic Clearance Rate
(drug effects)
- Triglycerides
(blood)
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