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Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.

Abstract
To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.
AuthorsT Wasada, K McCorkle, V Harris, K Kawai, B Howard, R H Unger
JournalThe Journal of clinical investigation (J Clin Invest) Vol. 68 Issue 4 Pg. 1106-7 (Oct 1981) ISSN: 0021-9738 [Print] United States
PMID7287903 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Chylomicrons
  • Gastrointestinal Hormones
  • Triglycerides
  • Gastric Inhibitory Polypeptide
Topics
  • Animals
  • Chylomicrons (blood)
  • Dogs
  • Gastric Inhibitory Polypeptide (pharmacology)
  • Gastrointestinal Hormones (pharmacology)
  • Metabolic Clearance Rate (drug effects)
  • Triglycerides (blood)

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