Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.

Abstract

The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was examined in guinea pigs. It was found that the D-manno- and D-galacto-type muramyldipeptides were as active as the D-gluco-type muramyldipeptide (MDP). The structural requirement of the carbohydrate moiety of analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine is discussed.

• Authors: I Azuma, H Okumura, I Saiki, M Kiso, A Hasegawa, Y Tanio, Y Yamamura
• Journal: Infection and immunity (Infect Immun) Vol. 33 Issue 3 Pg. 834-9 (Sep 1981) ISSN: 0019-9567 [Print] United States
• PMID: 7287186 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Azo Compounds
• Glycopeptides
• azobenzenearsonate-N-acetyl-L-tyrosine
• Tyrosine
• Acetylmuramyl-Alanyl-Isoglutamine
• p-Azobenzenearsonate

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (immunology)
• Adjuvants, Immunologic
• Animals
• Azo Compounds (adverse effects)
• Drug Hypersensitivity (etiology)
• Female
• Glycopeptides (immunology)
• Guinea Pigs
• Hypersensitivity, Delayed (chemically induced)
• Stereoisomerism
• Structure-Activity Relationship
• Tyrosine (adverse effects, analogs & derivatives)
• p-Azobenzenearsonate (adverse effects, analogs & derivatives)