[Molecular mechanisms of action of ethpenal].

Abstract

The effect of a new cholinolytic drug ethpenal, that is applied clinically as an antiparkinsonian and antiulcer agent, on the course of experimental myocardial infarction has been studied. The experiments have shown that in the test animals (white rats and rabbits) with myocardial infarction, ethpenal increases by 9.3% the contractile function of myofibrils, makes tissue respiration return to normal, and approximates the P/O magnitude to the control level. Administration of ethpenal to the animals with experimental myocardial infarction induces a considerable increase in the content of polyglycerophosphatides, which, in its turn, leads to stabilization of the cellular membranes. The drug improves permeability of the bilayer lecithin membranes by calcium ions. A conclusion is made that the myocardial infarction, ethpenal exerts a beneficial effect on the processes occurring at a level of the cellular membranes.

• Authors: V M Samvelian, E G Dzhanpoladian, S A Badzhinian
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1981 May-Jun Vol. 44 Issue 3 Pg. 299-303 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Nekotorye molekuliarnye mekhanizmy deĭstviia étpenala.
• PMID: 7286186 (Publication Type: English Abstract, Journal Article)

Chemical References

• Benzilates
• Diethylamines
• Lipid Bilayers
• Parasympatholytics
• ethpenal

Topics

• Animals
• Benzilates (pharmacology, therapeutic use)
• Diethylamines (pharmacology, therapeutic use)
• Lipid Bilayers
• Myocardial Contraction
• Myocardial Infarction (drug therapy)
• Myocardium (metabolism)
• Oxidative Phosphorylation
• Oxygen Consumption
• Parasympatholytics (therapeutic use)
• Permeability
• Rats