A pharmacodynamic and pharmacokinetic comparison of pindolol 20 mg retard and a conventional tablet.

Abstract

In 10 healthy volunteers the time course of cardiac beta-adrenoceptor blocking activity, plasma levels and cumulative urinary excretion of pindolol were compared during a 4-day course of pindolol 5 mg (Visken) t. d. s., and one tablet of pindolol 20 mg retard (Visken retard) once a day. After oral administration of the 20 mg retard tablet, plasma concentrations of pindolol higher than half the maximum value (1/2 Cp (tmax)) were maintained about 2.5 times as long as after administration of the conventional 5 mg tablet. This is evidence for an important and marked retardation of drug release. During treatment with pindolol 20 mg retard once daily, cardiac beta-adrenoceptor blockade, measured by the reduction in exercise-induced tachycardia and in the exercise-induced rise in systolic blood pressure, at almost all times throughout the 24 h period was at least as great as during treatment with pindolol 5 mg t. d. s. This suggests that patients successfully treated with pindolol 5 mg t. d. s. can be maintained with the same beta-adrenoceptor blockade by a single tablet of pindolol 20 mg retard once daily.

• Authors: W H Aellig, H H Narjes, E Nüesch, R J Oertle, J E Devos, W Pacha
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 20 Issue 3 Pg. 179-83 ( 1981) ISSN: 0031-6970 [Print] Germany
• PMID: 7286035 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Tablets
• Pindolol

Topics

• Administration, Oral
• Adult
• Blood Pressure (drug effects)
• Delayed-Action Preparations
• Heart Rate (drug effects)
• Humans
• Kinetics
• Male
• Pindolol (administration & dosage, metabolism, pharmacology)
• Tablets