Maleic vinyl ether activation of murine macrophages against lung-metastasizing tumors.

A 16,500 molecular weight fraction of maleic vinyl ether (MVE-2) induced tumoristatic and tumoricidal activity in peritoneal macrophages of BALB/c and C57BL/6 mice following i.p. administration. Growth of B16 melanoma cells in vitro was inhibited up to 85% by MVE-2-activated, but not resident, peritoneal macrophages. In a tritiated thymidine release assay, B16 melanoma cells, and to a lesser extent Madison 109 lung carcinoma cells, were also sensitive to the cytolytic action of MVE-2-activated peritoneal macrophages. Administration i.v. of MVE-2 resulted in tumoristatic and tumoricidal activity in alveolar macrophages against radiolabeled B16 and Madison 109 lung carcinoma target cells. MVE-2-activated alveolar macrophages significantly inhibited L5178Y lymphoma colony formation following a 48-hr macrophage-tumor cell coincubation. BALB/c mice bearing the lung-metastasizing Madison 109 lung carcinoma footpad tumor were given MVE-2 i.v., using the same dosing regimen that induced alveolar macrophages to be tumoricidal in vitro. Significant increases in life span were observed, suggesting that the antitumor activity of MVE-2 in this tumor system may be mediated by the activation of alveolar macrophages, with a resulting decrease in metastatic growth in the lung.
AuthorsS E Loveless, A E Munson
JournalCancer research (Cancer Res) Vol. 41 Issue 10 Pg. 3901-6 (Oct 1981) ISSN: 0008-5472 [Print] UNITED STATES
PMID7285000 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Polymers
  • Pyran Copolymer
  • Animals
  • Ascitic Fluid (cytology)
  • Cells, Cultured
  • Lung Neoplasms (immunology, secondary)
  • Macrophage Activation
  • Male
  • Melanoma (immunology)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Neoplasm Metastasis
  • Neoplasms, Experimental (immunology)
  • Polymers (pharmacology)
  • Pulmonary Alveoli (cytology)
  • Pyran Copolymer (pharmacology)

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