HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Riboflavin deficiency in man: effects on haemoglobin and reduced glutathione in erythrocytes of different ages.

Abstract
1. Erythrocytes (RBC) from control and marginally riboflavin-deficient subjects were fractionated into nine fractions using a discrete density gradient. 2. Glutathione reductase (NAD(P)H: glutathione oxidoreductase; EC 1.6.4.2) activity and aspartate aminotransferase (EC 2.6.1.1) activity (with and without the appropriate co-enzymes) reduced glutathione, methaemoglobin, sulphaemoglobin and oxyhaemoglobin and susceptibility to peroxide were measured in RBC in the different fractions. 3. Glutathione reductase and aspartate aminotransferase activities and concentrations of reduced glutathione and oxyhaemoglobin all declined with age, while methaemogloblin, sulphaemoglobin and susceptibility to peroxide increased with age. 4. The only significant differences noted in the RBC from marginally-riboflavin-deficient subjects by comparison with controls, were lower glutathione reductase activities and higher concentrations of methaemoglobin. 5. The role of riboflavin in those systems controlling RBC integrity is discussed.
AuthorsH J Powers, D I Thurnham
JournalThe British journal of nutrition (Br J Nutr) Vol. 46 Issue 2 Pg. 257-66 (Sep 1981) ISSN: 0007-1145 [Print] England
PMID7284295 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hemoglobins
  • Glutathione Reductase
  • Aspartate Aminotransferases
  • Glutathione
Topics
  • Aged
  • Aspartate Aminotransferases (blood)
  • Erythrocyte Aging
  • Erythrocytes (metabolism)
  • Glutathione (blood)
  • Glutathione Reductase (blood)
  • Hemoglobinometry
  • Hemoglobins (metabolism)
  • Hemolysis
  • Humans
  • Riboflavin Deficiency (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: