Ac2IDU, BVDU, and thymine arabinoside therapy in experimental herpes keratitis.

Abstract

The therapeutic efficacy of three new antiviral agents-5-iodo-3',5'-diacetyl-2'-deoxyuridine (diacetylidoxuridine, 1% Ac2IDU), E-5-(2-bromovinyl)-2'-deoxyuridine (0.25% BVDU), and 3% thymine arabinoside-is compared with available antivirals in an experimental model of herpes simplex virus type 1 (HSV-1) keratitis in New Zealand white rabbits. Compared with placebo, Ac2IDU significantly reduced ulcerative keratitis on days 4 through 8 after inoculation with virus and iritis on day 8 after inoculation. Compared with placebo, thymine arabinoside reduced ulcerative keratitis but not significantly. Thymine arabinoside caused significant iritis in all eyes. The epithelial disease in BVDU-treated eyes was significantly less than that in placebo-treated eyes on days 5 through 8 after inoculation. The results indicate that 1% Ac2IDU and 0.25% BVDU were effective in our ocular model of HSV-1 keratitis, whereas thymine arabinoside was not.

• Authors: M E Hettinger, D Pavan-Langston, N H Park, D M Albert, E De Clercq, T S Lin
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 99 Issue 9 Pg. 1618-21 (Sep 1981) ISSN: 0003-9950 [Print] United States
• PMID: 7283815 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Arabinonucleosides
• diacetylidoxuridine
• brivudine
• Sodium Chloride
• Petrolatum
• Vidarabine
• Bromodeoxyuridine
• Idoxuridine
• thymine arabinoside
• Thymidine

Topics

• Animals
• Antiviral Agents (adverse effects, therapeutic use)
• Arabinonucleosides (therapeutic use)
• Bromodeoxyuridine (analogs & derivatives, therapeutic use)
• Drug Evaluation, Preclinical
• Idoxuridine (analogs & derivatives, therapeutic use)
• Keratitis, Dendritic (drug therapy)
• Male
• Petrolatum (therapeutic use)
• Rabbits
• Sodium Chloride (therapeutic use)
• Thymidine (analogs & derivatives, therapeutic use)
• Vidarabine (therapeutic use)