Transplacental and neonatal carcinogenesis by 1-butyl-1-nitrosourethan in the ACI/N rat.

Abstract	1-Butyl-1-nitrosourethan (BNUR) and 1-butylurethane (BUR), a precursor of BNUR, were administered prenatally or neonatally to ACI/N rats. A few neurogenic tumors were induced in the offspring of mother rats that had received BNUR at the late stage of pregnancy and in the animals that had received one subcutaneous injection of BNUR within 24 hr after birth. No neurogenic tumors were observed in rats treated with BUR prenatally or neonatally.
Authors	A Maekawa, H Onodera, K Furuta, S Odashima
Journal	Gan (Gan) Vol. 71 Issue 6 Pg. 811-5 (Dec 1980) ISSN: 0016-450X [Print] Japan
PMID	7274627 (Publication Type: Journal Article)
Chemical References	Carcinogens Nitrosourea Compounds Urethane Nitrosomethylurethane N-n-butyl-N-nitrosourethane N-nitrosobutylurea
Topics	Animals Animals, Newborn Brain Neoplasms (chemically induced) Carcinogens (toxicity) Female Fetus (drug effects) Maternal-Fetal Exchange Neoplasms (chemically induced) Nitrosomethylurethane (analogs & derivatives, toxicity) Nitrosourea Compounds (toxicity) Pregnancy Rats Urethane (analogs & derivatives) Urinary Bladder Neoplasms (chemically induced)

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