Abstract |
With the use of Ag staining and conventional light microscopy, a difference is visualized in the frequency of nucleolar organizer regions between PHA-stimulated lymphocytes from normal females and females with various types of adenocarcinoma. This difference in NOR activity is more pronounced in G chromosome than D chromosomes. It is feasible that rDNA gene activity in PHA-stimulated lymphocytes is augmented in patients with adenocarcinoma due to the presence of plasma mediators arising from cellular malignancies. The NOR regions located on G chromosomes are considered to be more sensitive to these mediators than those on D chromosomes.
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Authors | D M Cheng, T E Denton, S L Liem, C L Elliot |
Journal | Clinical genetics
(Clin Genet)
Vol. 19
Issue 3
Pg. 145-8
(Mar 1981)
ISSN: 0009-9163 [Print] Denmark |
PMID | 7273456
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ribosomal Proteins
- Silver
|
Topics |
- Adenocarcinoma
(genetics)
- Adult
- Aged
- Chromosomes, Human, 13-15
- Chromosomes, Human, 21-22 and Y
- Female
- Genetic Variation
- Humans
- Lymphocytes
(pathology)
- Middle Aged
- Nucleolus Organizer Region
(pathology)
- Ribosomal Proteins
(genetics)
- Silver
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