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Influence of total dose and dose schedule on induction of urinary bladder cancer in the mouse by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Abstract
Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear increase in carcinoma incidence with dose. OH-BBN administration schedule had a significant effect on cancer incidence: administration of a total dose of 30, 20, or 15 mg OH-BBN in 20 weekly fractions was more effective in cancer induction than was the same total dose given in 5 fractions. A 10 dose administration schedule was of intermediate efficacy. The data obtained indicate that OH-BBN induces urinary bladder cancers in BDF mice in a dose-related manner, with high target organ-specificity, little toxicity, and short tumor latency; induced tumors are primarily transitional cell carcinomas which morphologically resemble their human counterpart. Administration of OH-BBN mice provides a useful model for the experimental study of urinary bladder cancer.
AuthorsD L McCormick, S S Ronan, P J Becci, R C Moon
JournalCarcinogenesis (Carcinogenesis) Vol. 2 Issue 3 Pg. 251-4 ( 1981) ISSN: 0143-3334 [Print] England
PMID7273310 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Carcinogens
  • Nitrosamines
  • Butylhydroxybutylnitrosamine
Topics
  • Animals
  • Butylhydroxybutylnitrosamine (pharmacology)
  • Carcinogens
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Male
  • Mice
  • Neoplasms, Experimental (chemically induced)
  • Nitrosamines (pharmacology)
  • Urinary Bladder Neoplasms (chemically induced)

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