Abstract |
Heart failure was induced in barbital-anesthetized dogs by administering high doses of pentobarbital. This procedure depresses cardiac function as indicated by a reduction in right ventricular contractile force (RVCF), left ventricular dp/dt and aortic blood flow. Bucindolol (0.1 mg/kg and 0.1 mg/kg/hr) elicited a pronounced and prolonged stimulant effect on these depressed indicators of cardiac function. Both RVCF and aortic blood flow returned to pre-failure levels, left ventricular dp/dt increased 43% but heart rate was elevated only slightly (14%). Total peripheral resistance was lowered 36% by bucindolol. The combination of myocardial stimulation and vasodilatation which contributed to the positive results in this acute model of pump failure suggests a possible role for bucindolol in the clinical management of congestive heart failure. Further these results suggest that bucindolol, in contrast to propranolol, could also be used in a sub-group of hypertensive patients with depressed cardiac function.
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Authors | D Deitchman, R W Snyder |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
Vol. 250
Issue 1
Pg. 65-72
(Mar 1981)
ISSN: 0003-9780 [Print] Belgium |
PMID | 7271381
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Indoles
- Propanolamines
- bucindolol
- Pentobarbital
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Dogs
- Female
- Heart Failure
(chemically induced, complications, drug therapy)
- Heart Rate
(drug effects)
- Hypertension
(complications)
- Indoles
(therapeutic use)
- Male
- Pentobarbital
- Propanolamines
(therapeutic use)
- Vascular Resistance
(drug effects)
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