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Beneficial effects of bucindolol in a canine model of pentobarbital-induced heart failure.

Abstract
Heart failure was induced in barbital-anesthetized dogs by administering high doses of pentobarbital. This procedure depresses cardiac function as indicated by a reduction in right ventricular contractile force (RVCF), left ventricular dp/dt and aortic blood flow. Bucindolol (0.1 mg/kg and 0.1 mg/kg/hr) elicited a pronounced and prolonged stimulant effect on these depressed indicators of cardiac function. Both RVCF and aortic blood flow returned to pre-failure levels, left ventricular dp/dt increased 43% but heart rate was elevated only slightly (14%). Total peripheral resistance was lowered 36% by bucindolol. The combination of myocardial stimulation and vasodilatation which contributed to the positive results in this acute model of pump failure suggests a possible role for bucindolol in the clinical management of congestive heart failure. Further these results suggest that bucindolol, in contrast to propranolol, could also be used in a sub-group of hypertensive patients with depressed cardiac function.
AuthorsD Deitchman, R W Snyder
JournalArchives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 250 Issue 1 Pg. 65-72 (Mar 1981) ISSN: 0003-9780 [Print] Belgium
PMID7271381 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Indoles
  • Propanolamines
  • bucindolol
  • Pentobarbital
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Dogs
  • Female
  • Heart Failure (chemically induced, complications, drug therapy)
  • Heart Rate (drug effects)
  • Hypertension (complications)
  • Indoles (therapeutic use)
  • Male
  • Pentobarbital
  • Propanolamines (therapeutic use)
  • Vascular Resistance (drug effects)

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