Febrile morbidity following cefamandole nafate intrauterine irrigation during cesarean section.

Abstract

The effectiveness of intrauterine irrigation during cesarean section with a solution of cefamandole nafate in reducing febrile morbidity was studied in a prospective double-blind fashion. Ninety patients who were undergoing cesarean section at Tripler Army Medical Center were randomized into three groups: (1) intrauterine irrigation with cefamandole nafate solution, (2) intrauterine irrigation with normal saline solution, and (3) no irrigation. Febrile morbidity was evaluated by means of a fever index. There was a statistically significant reduction in the fever index in the group that received intrauterine irrigation with cefamandole nafate. The incidences of clinically diagnosed endomyometritis in the three groups were 0%, 26.7%, and 23.3%, respectively. Prophylactic intrauterine irrigation with cefamandole nafate during cesarean section markedly reduces febrile morbidity, primarily by reducing the incidence of endomyometritis.

• Authors: E G Rudd, W H Long, M B Dillon
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 141 Issue 1 Pg. 12-6 (Sep 01 1981) ISSN: 0002-9378 [Print] United States
• PMID: 7270617 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Cefamandole

Topics

• Cefamandole (administration & dosage, therapeutic use)
• Cephalosporins (therapeutic use)
• Cesarean Section
• Double-Blind Method
• Endometritis (epidemiology, prevention & control)
• Female
• Fever (epidemiology, prevention & control)
• Humans
• Intraoperative Care
• Postoperative Complications (prevention & control)
• Pregnancy
• Prospective Studies
• Puerperal Infection (prevention & control)
• Risk
• Therapeutic Irrigation
• Uterus