Treatment of Methaqualone overdose with resin hemoperfusion.

Abstract

We recently utilized the technique of resin hemoperfusion (employing an Amberlite XAD-4 resin cartridge) to remove drug from a patient i deep coma after an estimated ingestion of greater than 4.5 grams of methaqualone. At plasma flow rates of 204 ml/min, the mean value for plasma clearance of methaqualone was 179 ml/min. The amount of methaqualone recovered from the cartridge at the end of the 10-hour procedure was 1,565 mg measured by gas chromatography. The patient became responsive to deep pain by the end of the procedure. The only complication encountered was a transient decrease in the formed blood elements. The present study verifies that a large, pharmacologically significance quantity of methaqualone can be removed in a short time using resin hemoperfusion.

• Authors: D Baggish, S Gray, P Jatlow, M J Bia
• Journal: The Yale journal of biology and medicine (Yale J Biol Med) 1981 Mar-Apr Vol. 54 Issue 2 Pg. 147-50 ISSN: 0044-0086 [Print] United States
• PMID: 7269641 (Publication Type: Case Reports, Journal Article)

Chemical References

• Resins, Plant
• Methaqualone

Topics

• Adult
• Hemoperfusion
• Humans
• Male
• Methaqualone (poisoning)
• Resins, Plant (administration & dosage)