Abstract |
Rabbits have been epicutaneously exposed to pure hexachlorobutadiene (0.25; 0.50; 0.75 and 1.00 ml/kg) during 8 hrs. This solvent was completely absorbed; some animals died within 24 hrs and others a few days later. The LD50 is 0.72 ml/kg (Bliss' method). Hexachlorobutadiene induced in situ cutaneous necrosis and its absorption induced systemic damage ( fatty liver degeneration and epithelial necrotizing nephritis). These lesions are reversible. The present results confirm the toxicological profile of this solvent, previously established by the intraperitoneal and oral routes: hexachlorobutadiene is the most nephrotoxic aliphatic chlorinated hydrocarbon.
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Authors | P Duprat, D Gradiski |
Journal | Acta pharmacologica et toxicologica
(Acta Pharmacol Toxicol (Copenh))
Vol. 43
Issue 5
Pg. 346-53
(Nov 1978)
ISSN: 0001-6683 [Print] Denmark |
PMID | 726900
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Topical
- Animals
- Butadienes
(administration & dosage, toxicity)
- Chemical and Drug Induced Liver Injury
(pathology)
- Fatty Liver
(chemically induced)
- Female
- Kidney
(drug effects, pathology)
- Lethal Dose 50
- Liver
(drug effects, pathology)
- Necrosis
- Nephritis
(chemically induced)
- Rabbits
- Skin
(drug effects, pathology)
- Skin Absorption
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