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Percutaneous toxicity of hexachlorobutadiene.

Abstract
Rabbits have been epicutaneously exposed to pure hexachlorobutadiene (0.25; 0.50; 0.75 and 1.00 ml/kg) during 8 hrs. This solvent was completely absorbed; some animals died within 24 hrs and others a few days later. The LD50 is 0.72 ml/kg (Bliss' method). Hexachlorobutadiene induced in situ cutaneous necrosis and its absorption induced systemic damage (fatty liver degeneration and epithelial necrotizing nephritis). These lesions are reversible. The present results confirm the toxicological profile of this solvent, previously established by the intraperitoneal and oral routes: hexachlorobutadiene is the most nephrotoxic aliphatic chlorinated hydrocarbon.
AuthorsP Duprat, D Gradiski
JournalActa pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 43 Issue 5 Pg. 346-53 (Nov 1978) ISSN: 0001-6683 [Print] Denmark
PMID726900 (Publication Type: Journal Article)
Chemical References
  • Butadienes
Topics
  • Administration, Topical
  • Animals
  • Butadienes (administration & dosage, toxicity)
  • Chemical and Drug Induced Liver Injury (pathology)
  • Fatty Liver (chemically induced)
  • Female
  • Kidney (drug effects, pathology)
  • Lethal Dose 50
  • Liver (drug effects, pathology)
  • Necrosis
  • Nephritis (chemically induced)
  • Rabbits
  • Skin (drug effects, pathology)
  • Skin Absorption

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