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Potential anticonvulsants. 1. 5-Benzylhydantoins.

Abstract
A selected group of alkoxy- and halogen-substituted 5-benzylidino- and 5-benzylhydantoins was prepared and screened for anticonvulsant activity as measured by the ability of the compound to prevent maximal electroshock and metrazol-induced threshold clonic seizures in rats. The structure-activity studies revealed 5-[3-(trifluoromethyl)benzyl]hydantoin (14) to be the most potent member of the series.
AuthorsN B Mehta, C A Diuguid, F E Soroko
JournalJournal of medicinal chemistry (J Med Chem) Vol. 24 Issue 4 Pg. 465-8 (Apr 1981) ISSN: 0022-2623 [Print] United States
PMID7265133 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Hydantoins
  • 5-benzylhydantoin
Topics
  • Animals
  • Anticonvulsants (chemical synthesis, pharmacology)
  • Drug Evaluation, Preclinical
  • Hydantoins (chemical synthesis, pharmacology)
  • Male
  • Mice
  • Rats
  • Seizures (drug therapy)
  • Structure-Activity Relationship

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