Abstract |
A selected group of alkoxy- and halogen-substituted 5-benzylidino- and 5-benzylhydantoins was prepared and screened for anticonvulsant activity as measured by the ability of the compound to prevent maximal electroshock and metrazol-induced threshold clonic seizures in rats. The structure-activity studies revealed 5-[3-(trifluoromethyl)benzyl] hydantoin (14) to be the most potent member of the series.
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Authors | N B Mehta, C A Diuguid, F E Soroko |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 24
Issue 4
Pg. 465-8
(Apr 1981)
ISSN: 0022-2623 [Print] United States |
PMID | 7265133
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Hydantoins
- 5-benzylhydantoin
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Topics |
- Animals
- Anticonvulsants
(chemical synthesis, pharmacology)
- Drug Evaluation, Preclinical
- Hydantoins
(chemical synthesis, pharmacology)
- Male
- Mice
- Rats
- Seizures
(drug therapy)
- Structure-Activity Relationship
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