Amyloidosis in (CBA/J X A/J)F2 mice: correlation of amyloid resistance and low mitogenic response to concanavalin A.

Abstract

A/J mice are highly resistant to induction of amyloidosis with serial injections of azocasein, compared to the CBA/J strain. (CBA X A) F2 hybrid mice were treated with azocasein, after spleen biopsy for assay of 3 immunologic functions differing in the parent strains. The proportions of amyloid susceptibility and resistance in the hybrid population conformed to the expectations for a single gene. Low responses to the T cell mitogen concanavalin A correlated with resistance to amyloid induction, whereas the response to lipopolysaccharide and the level of natural killer activity were independent of susceptibility to amyloidosis.

• Authors: J R Wohlgethan, E S Cathcart
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 127 Issue 3 Pg. 1003-7 (Sep 1981) ISSN: 0022-1767 [Print] United States
• PMID: 7264297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Caseins
• Lipopolysaccharides
• azocasein
• Concanavalin A

Topics

• Amyloidosis (etiology, immunology)
• Animals
• Caseins (analogs & derivatives, pharmacology)
• Concanavalin A (pharmacology)
• Crosses, Genetic
• Cytotoxicity, Immunologic
• Hybridization, Genetic
• Lipopolysaccharides (pharmacology)
• Mice
• Mice, Inbred A (genetics, immunology)
• Mice, Inbred CBA (genetics, immunology)