HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Urinary excretion levels of unconjugated pterins in cancer patients and normal individuals.

Abstract
Urinary excretion levels of seven unconjugated pterins in healthy individuals and in cancer patients, most of whom were undergoing chemotherapy, were measured utilizing a newly developed high-pressure liquid chromatographic system. Excretion of pterins in the control group appears to be under strict metabolic control as the values obtained were confined within a small range. When the mean excretion levels in control subjects were compared with those in cancer patients, we found a significant increase in the excretion of xanthopterin, neopterin and pterin and a significant decrease in isoxanthopterin by cancer patients. Biopterin levels, on the other hand, were found only slightly but not significantly increased, whereas pterin-6-carboxylic acid and 6-hydroxymethylpterin were found to be excreted in approximately equal amounts in both groups. Urinary excretion levels of pterins were monitored for a period of nine months in a patient being treated with chemotherapy for metastatic ovarian carcinomatosis. We found that the excretion pattern of pterins appeared to correlate with the clinical status of the patient. These results indicate that a definite imbalance in pterin, and possibly folate metabolism, is associated with the presence of malignant diseases.
AuthorsB Stea, R M Halpern, B C Halpern, R A Smith
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 113 Issue 3 Pg. 231-42 (Jul 01 1981) ISSN: 0009-8981 [Print] Netherlands
PMID7261396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Pterins
  • Biopterin
  • isoxanthopterin
  • Neopterin
  • Xanthopterin
Topics
  • Adult
  • Aged
  • Biopterin (analogs & derivatives, urine)
  • Carcinoma (urine)
  • Female
  • Humans
  • Middle Aged
  • Neoplasms (drug therapy, urine)
  • Neopterin
  • Ovarian Neoplasms (urine)
  • Prognosis
  • Pterins (urine)
  • Xanthopterin (urine)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: