Pancreatic carcinogenic effect of N-nitrosobis (2-oxobutyl) amine and N-nitroso (2-oxobutyl) (2-oxopropyl) amine in Syrian hamster.

Abstract

A single subcutaneous injection of N-nitrosobis(2-oxobutyl)amine (BOB) and N-nitroso(2-oxobutyl)(2-oxopropyl)amine (OBOB) induced a high incidence of pancreatic ductular neoplasms in Syrian hamsters. Both compounds showed a cytotoxic effect on pancreatic islet cells in toxic doses. Since both compounds, like N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), can form cyclic structures resembling the hexose sugars and the glucose-moiety of the streptozotocin, it can be assumed that the ability of these 2 carcinogens to cyclize is important in their affinity for the pancreas. However, OBOP had a greater pancreatic carcinogenic effect than BOB, the primary target tissue of which was the liver. Hence factors other than cyclization, such as the presence of the 2-oxo group in the aliphatic chains, also appear to be important for the pancreatic carcinogenicity of this class of nitrosamines.

• Authors: P M Pour, C R Raha
• Journal: Cancer letters (Cancer Lett) Vol. 12 Issue 3 Pg. 223-9 (Apr 1981) ISSN: 0304-3835 [Print] Ireland
• PMID: 7260892 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Nitrosamines
• N-nitrosobis(2-oxobutyl)amine
• N-nitroso(2-oxobutyl)(2-oxopropyl)amine

Topics

• Animals
• Carcinogens
• Cricetinae
• Cyclization
• Female
• Male
• Mesocricetus
• Nitrosamines (pharmacology)
• Pancreatic Neoplasms (chemically induced)
• Structure-Activity Relationship