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Disseminated spiked hyperkeratosis. An unusual discrete nonfollicular keratinization disorder.

Abstract
An unusual nonfollicular keratinization disorder was observed in a father and his son, and in an unrelated woman. The disorder began during the second decade of life and gradually became more widespread and more pronounced thereafter. The dermatosis is characterized by tiny, rough, keratotic spikes giving the skin a raspy fell on palpation. Microscopically, the lesions showed a thick compact corneum without structural changes in the underlying epidermis except for moderate epidermal cell hyperplasia and some reduction in keratohyalin content.
AuthorsE Frenk, B Mevorah, F Leu
JournalArchives of dermatology (Arch Dermatol) Vol. 117 Issue 7 Pg. 412-4 (Jul 1981) ISSN: 0003-987X [Print] United States
PMID7259220 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Epidermis (pathology)
  • Female
  • Humans
  • Hyperplasia
  • Keratosis (genetics, pathology)
  • Male
  • Middle Aged
  • Skin (pathology, ultrastructure)

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