[Effect of carbostimulin on metabolism in rats with deep burns].

Abstract

It is established that at early stages of the burn disease (deep burn of III-B degree, 20% of body surface) in rats there appears metabolic acidosis, the content of urea increases in the liver and blood serum, a pronounced hydration of the liver and muscles is observed in the burn zone. Administration per os of carbostimulin just a day after burn removes symptoms of metabolic acidosis. When the preparation is fed to rats during 7 days after burn the intensity of radioactive label incorporation into proteins, lipid and glycogen of the liver as well as in proteins and lipids of kidneys and spleen increases.

• Authors: N A Stogniĭ, G I Zhurbin, V V Sushkova, V S Kul'baka, M F Gulyĭ
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1981 May-Jun Vol. 53 Issue 3 Pg. 99-103 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Vliianie karbostimulina na obmen veshchestv u krys pri ozhogovoĭ bolezni.
• PMID: 7256958 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbonates
• Drug Combinations
• Lipids
• Liver Glycogen
• Manganese Compounds
• Zinc Compounds
• Manganese
• Carbostimulin
• Magnesium Sulfate
• Urea
• Zinc

Topics

• Acidosis (drug therapy, etiology)
• Animals
• Burns (metabolism)
• Carbonates (metabolism, therapeutic use)
• Drug Combinations (metabolism, therapeutic use)
• Lipids (biosynthesis)
• Liver (drug effects, metabolism)
• Liver Glycogen (biosynthesis)
• Magnesium Sulfate (metabolism, therapeutic use)
• Male
• Manganese (metabolism, therapeutic use)
• Manganese Compounds
• Muscles (drug effects, metabolism)
• Protein Biosynthesis
• Rats
• Spleen (metabolism)
• Urea (metabolism)
• Zinc (metabolism, therapeutic use)
• Zinc Compounds