Central action of mepiprazole.

Abstract

Mepiprazole, a phenylpiperazine derivative, strongly antagonizes the behavioral syndromes evolved by 5-hydroxytrypotophan. The drug did not affect the serotonin neurons in the preparation of flexor reflex of the hind paw of the spinal rat: in higher doses it depressed the reflex showing noradrenolytic properties. Mepiprazole antagonized the fenfluramine-induced hyperthermia, depressed spontaneous locomotor activity, produce hypothermia and was inactive in the despair test. The results suggest that mepiprazol may have noradenolytic properties; its possible influence on the serotonergic system is masked by noradrenolytic properties and hence difficult to demonstrate.

• Authors: J Maj, M Sypniewska
• Journal: Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) 1980 Jul-Aug Vol. 32 Issue 4 Pg. 475-84 ISSN: 0301-0244 [Print] Poland
• PMID: 7255266 (Publication Type: Journal Article)

Chemical References

• Piperazines
• Pyrazoles
• Receptors, Adrenergic
• Receptors, Serotonin
• Tranquilizing Agents
• mepiprazole
• Trazodone

Topics

• Animals
• Behavior, Animal (drug effects)
• Body Temperature (drug effects)
• Brain (drug effects)
• Immobilization (drug effects)
• Male
• Motor Activity (drug effects)
• Piperazines (pharmacology)
• Pyrazoles (pharmacology)
• Rats
• Receptors, Adrenergic (drug effects)
• Receptors, Serotonin (drug effects)
• Reflex (drug effects)
• Tranquilizing Agents (pharmacology)
• Trazodone (metabolism)