Cytotoxicity and the effect of combined treatment with X-rays of an anticancer 1-nitro-9-aminoacridine derivative in L5178Y-R and L5178Y-S cells.

The response to nitracrine, 1-nitro-9-[3'(N,N-dimethyl)aminopropyl] aminoacridine, an anticancer agent, was examined in two strains of murine lymphoma L5178Y inversely cross-sensitive to X-rays and UV light. A marked difference was found in sensitivity to the drug between L5178Y-R and L5178Y-S strain (D0 values 2.1 and 13.9 ng/ml, 3 h, 37 degrees C); survival was related to the yield of chromatid aberrations. Enhanced sensitivity of L5178Y-R cells to nitracrine as well as to UV light and an antitumor platinum complex has been ascribed to the previously found defect in post-replication repair in these cells. Combined treatment with nitracrine and X-rays under oxic conditions gave additive effects in both L5178Y strains.
AuthorsI Szumiel, M Walicka
JournalNeoplasma (Neoplasma) Vol. 27 Issue 6 Pg. 697-702 ( 1980) ISSN: 0028-2685 [Print] CZECHOSLOVAKIA
PMID7254425 (Publication Type: Journal Article)
Chemical References
  • Aminoacridines
  • Nitracrine
  • Aminoacridines (therapeutic use)
  • Animals
  • Cell Survival (drug effects, radiation effects)
  • Chromatids (pathology)
  • Chromosomes
  • Lymphoma (drug therapy, pathology, radiotherapy)
  • Mice
  • Neoplasms, Experimental (drug therapy, pathology)
  • Nitracrine (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: