HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analysis of carminomycin in human serum by fluorometric high-performance liquid chromatography.

Abstract
A method is given for the determination of carminomycin (CMM) and a major metabolite carminomycinol (CMMOH) in serum from cancer patients after intravenous administration of carminomycin as the free drug. CMM and CMMOH are extracted from serum with chloroform, the extract evaporated and the residue dissolved in methanol. High performance liquid chromatography analysis utilized a C18 microBondapak reversed-phase column eluted with 0.1 mol/l acetate buffer (pH 4)-acetonitrile (60:40, v/v) with fluorescence detection. The assay is linear, reproducible, and precise with a limit of detection of 2 ng/ml. Representative serum levels of CMM and CMMOH in a cancer patients are presented.
AuthorsS E Fandrich, K A Pittman
JournalJournal of chromatography (J Chromatogr) Vol. 223 Issue 1 Pg. 155-64 (Apr 10 1981) Netherlands
PMID7251757 (Publication Type: Journal Article)
Chemical References
  • Carubicin
  • Daunorubicin
Topics
  • Analysis of Variance
  • Carubicin (administration & dosage, blood, metabolism)
  • Chromatography, High Pressure Liquid (methods)
  • Daunorubicin (analogs & derivatives)
  • Humans
  • Injections, Intravenous
  • Neoplasms (blood)
  • Reference Standards
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: