Experimental studies of tumor radioimmunodetection using antibody mixtures against carcinoembryonic antigen (CEA) and colon-specific antigen-p (CSAp).

Abstract

Experiments with the GW-39 human colonic carcinoma growing in hamsters showed that injection of radioactive antibody to a colorectal-specific, tumor-associated antigen, CSAp, results in better tumor radiolocalization than was seen previously with radioantibodies to carcinoembryonic antigen (CEA). However, a mixture of both radioactive antibodies resulted in potentiation of CEA-tumor radioimmunodetection without affecting CSAp-tumor radiolocalization. Hence, multi-marker antibody mixtures may be the method of choice in cancer radioimmunodetection.

• Authors: S A Gaffar, K D Pant, D Shochat, S J Bennett, D M Goldenberg
• Journal: International journal of cancer (Int J Cancer) Vol. 27 Issue 1 Pg. 101-5 (Jan 15 1981) ISSN: 0020-7136 [Print] United States
• PMID: 7251228 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Neoplasm
• Antigens, Neoplasm
• Carcinoembryonic Antigen

Topics

• Animals
• Antibodies, Neoplasm (immunology)
• Antigens, Neoplasm (immunology)
• Carcinoembryonic Antigen (immunology)
• Colonic Neoplasms (diagnostic imaging, immunology)
• Cricetinae
• Goats
• Humans
• Neoplasms, Experimental (diagnostic imaging, immunology)
• Radionuclide Imaging