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Effect of topical diflumidone on ultraviolet-light-induced erythema.

Abstract
The relative topical efficacy of indomethacin and diflumidone, a novel non-steroidal antiinflammatory drug, for the suppression of ultraviolet-light (290-320 nm region; UVB)-induced erythema has been compared in a randomized, double-blind, placebo-controlled study in man. During the early phases of erythema development (3-6 h) following the administration of 3 minimal erythema doses (MED) of UVB, a single topical application of diflumidone and of indomethacin were found to be equal in their ability to inhibit the development of erythema compared to untreated or placebo-treated sites. At 24 h after application, the indomethacin-treated sites had significantly less erythema than did the diflumidone-treated sites. Pigmentation of test sites at 5 and 14 days following irradiation was indistinguishable at the diflumidone, placebo, or untreated sites, but relatively less pigment developed at the indomethacin-treated sites.
AuthorsE C Gomez, R J Trancik
JournalDermatologica (Dermatologica) Vol. 162 Issue 3 Pg. 175-82 ( 1981) ISSN: 0011-9075 [Print] Switzerland
PMID7250461 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Benzophenones
  • Sulfonamides
  • diflumidone
  • Indomethacin
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Benzophenones (therapeutic use)
  • Erythema (drug therapy, etiology)
  • Humans
  • Indomethacin (therapeutic use)
  • Middle Aged
  • Pigmentation Disorders (drug therapy)
  • Sulfonamides (therapeutic use)
  • Ultraviolet Rays (adverse effects)

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