Cephamycin C treatment of induced swine salmonellosis.

Abstract

Weanling pigs in groups of 12 were infected orally with Salmonella choleraesuis and were treated intramuscularly with doses of cephamycin C ranging from 12.5 to 337.5 mg twice daily for 10 days beginning 1 day postinoculation. Pigs in two other infected groups either received 300 mg of tetracycline orally on a similar schedule or served as nonmedicated controls. Optimal responses to cephamycin C were achieved at a twice daily dose of 112.5 mg. With this regimen, the febrile response was significantly reduced on day 2 and eliminated by day 5 postinfection, and the shedding of Salmonella spp. in feces was eliminated by day 5 postinfection; essentially, no lesions were found in the gastrointestinal tract at necropsy (day 26 postinfection). There was no mortality among recipients of the 112.5-mg dose; diarrhea was present on only 2% of the observation days. In contrast, 83% of the infected, nonmedicated pigs and 25% of the tetracycline-medicated pigs died, and diarrhea was present in these groups on 63 and 54% of the observation days, respectively. The striking benefits of cephamycin C treatment was achieved without adverse reactions. The weight gain and feed efficiency of the infected pigs treated with the 112.5-mg dose of cephamycin C and the noninfected, nonmedicated control pigs were equivalent.

• Authors: T M Jacks, C J Welter, G R Fitzgerald, B M Miller
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 19 Issue 4 Pg. 562-6 (Apr 1981) ISSN: 0066-4804 [Print] United States
• PMID: 7247378 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Cephamycins
• Tetracycline
• cephamycin C

Topics

• Animals
• Cephalosporins (therapeutic use)
• Cephamycins (therapeutic use)
• Feces (microbiology)
• Female
• Male
• Salmonella Infections, Animal (drug therapy, microbiology)
• Swine
• Swine Diseases (drug therapy)
• Tetracycline (therapeutic use)