[Effect of amino acid imbalance and ascorbic acid deficit on the carcinogenic effect of N-nitrosopiperidine].

Abstract

A study was made of the effect of ascorbic acid deficiency and low levels of lysine, methionine and threonine on the cancerogenic effect of nitrosopiperidine which was fed to guinea-pigs with drinking water in a single dose of 4.25 mg/kg bw. Deficiency of the nutrients given alone or especially in combination speeded up the growth tumors induced by the cancerogenic agent. A possibility of inducing esophageal tumors in guinea-pigs has been demonstrated for the first time.

• Authors: T Sh Sharmanov, M M Aĭdzhanov, N I Kolycheva
• Journal: Voprosy pitaniia (Vopr Pitan) 1981 Mar-Apr Issue 2 Pg. 5-10 ISSN: 0042-8833 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie disbalansa aminokislot i defitsita askorbinovoĭ kisloty na kantserogennyĭ éffekt N-nitrozopiperidina.
• PMID: 7245695 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Nitrosamines
• Piperidines
• N-nitrosopiperidine

Topics

• Amino Acids (deficiency)
• Animal Feed
• Animals
• Ascorbic Acid Deficiency (complications)
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Esophageal Neoplasms (chemically induced, pathology)
• Guinea Pigs
• Neoplasms, Experimental (chemically induced, pathology)
• Nitrosamines (pharmacology)
• Piperidines (pharmacology)
• Stomach Neoplasms (chemically induced, pathology)
• Time Factors