Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Abstract

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylphenol) or 4,4'-methylenebis(2,6-di-tert-butylphenol) at a level of 1.135 mmol% for 1 week. 4,4'-Butylidenebis(3-methyl-6-tert-butylphenol) induced fatty liver and increased triglyceride, diglyceride and cholesteryl-ester concentrations, 7.1-, 5.8- and 6.1-fold, respectively. Plasma triglycerides, total cholesterol and non-esterified fatty acids were markedly decreased. It would appear that the fatty liver resulted mainly from defective fat excretion from the liver. The other bisphenols produced a little change in liver lipids.

• Authors: O Takahashi, K Hiraga
• Journal: Toxicology letters (Toxicol Lett) Vol. 8 Issue 1-2 Pg. 77-86 (Apr 1981) ISSN: 0378-4274 [Print] Netherlands
• PMID: 7245245 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Lipids
• Butylated Hydroxytoluene
• 4,4'-methylenebis(2,6-di-tert-butylphenol)
• Santowhite powder
• 2,2'-methylenebis(4-methyl-6-tert-butylphenol)
• 2,2'-methylenebis(ethyl-6-tert-butylphenol)

Topics

• Animals
• Antioxidants (poisoning)
• Butylated Hydroxytoluene (analogs & derivatives, poisoning)
• Fatty Liver (chemically induced)
• Lipids (analysis)
• Liver (analysis, drug effects)
• Male
• Rats