Elimination pattern and biodistribution of [14C]chlorferron in rats.

Abstract

Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-derived residues were detected in all analyzed organs. These findings indicated that chlorferron was absorbed from the gastro-intestinal tract in appreciable quantities, but was rapidly excreted mainly via the urine with small amounts only in the faeces.

• Authors: J K Malik, J P Lay, W Klein, F Korte
• Journal: Toxicology letters (Toxicol Lett) Vol. 7 Issue 6 Pg. 449-52 (Mar 1981) ISSN: 0378-4274 [Print] Netherlands
• PMID: 7245230 (Publication Type: Journal Article)

Chemical References

• Coumarins
• Umbelliferones
• chlorferron

Topics

• Animals
• Biotransformation
• Coumarins (metabolism)
• Feces (analysis)
• Female
• Intestinal Absorption
• Rats
• Tissue Distribution
• Umbelliferones