Abstract |
A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.
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Authors | E J Wilkinson, E G Friedrich Jr, Y S Fu |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 58
Issue 1
Pg. 69-74
(Jul 1981)
ISSN: 0029-7844 [Print] United States |
PMID | 7243148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Carcinoma in Situ
(analysis, pathology)
- Cell Cycle
- DNA, Neoplasm
(analysis)
- Female
- Humans
- Spectrophotometry
- Vulva
(pathology)
- Vulvar Neoplasms
(analysis, pathology)
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