Multicentric nature of vulvar carcinoma in situ.

A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.
AuthorsE J Wilkinson, E G Friedrich Jr, Y S Fu
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 58 Issue 1 Pg. 69-74 (Jul 1981) ISSN: 0029-7844 [Print] UNITED STATES
PMID7243148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA, Neoplasm
  • Carcinoma in Situ (analysis, pathology)
  • Cell Cycle
  • DNA, Neoplasm (analysis)
  • Female
  • Humans
  • Spectrophotometry
  • Vulva (pathology)
  • Vulvar Neoplasms (analysis, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: