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Multicentric nature of vulvar carcinoma in situ.

Abstract
A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.
AuthorsE J Wilkinson, E G Friedrich Jr, Y S Fu
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 58 Issue 1 Pg. 69-74 (Jul 1981) ISSN: 0029-7844 [Print] UNITED STATES
PMID7243148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA, Neoplasm
Topics
  • Carcinoma in Situ (analysis, pathology)
  • Cell Cycle
  • DNA, Neoplasm (analysis)
  • Female
  • Humans
  • Spectrophotometry
  • Vulva (pathology)
  • Vulvar Neoplasms (analysis, pathology)

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