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Is glutamate a trigger factor in epileptic hyperactivity?

Abstract
The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL-Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino-adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.
AuthorsJ Coutinho-Netto, A S Abdul-Ghani, J F Collins, H F Bradford
JournalEpilepsia (Epilepsia) Vol. 22 Issue 3 Pg. 289-96 (Jun 1981) ISSN: 0013-9580 [Print] United States
PMID7238433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Aminobutyrates
  • Excitatory Amino Acid Antagonists
  • Glutamates
  • Organophosphorus Compounds
  • Aspartic Acid
  • 2-amino-4-phosphonobutyric acid
Topics
  • Amino Acids (analysis)
  • Aminobutyrates (pharmacology)
  • Animals
  • Aspartic Acid (antagonists & inhibitors)
  • Cerebral Cortex (analysis)
  • Electroencephalography
  • Epilepsy (etiology, physiopathology)
  • Excitatory Amino Acid Antagonists
  • Female
  • Glutamates (physiology)
  • Organophosphorus Compounds (pharmacology)
  • Rats
  • Seizures (etiology)

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