Abstract |
The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL- Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino- adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.
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Authors | J Coutinho-Netto, A S Abdul-Ghani, J F Collins, H F Bradford |
Journal | Epilepsia
(Epilepsia)
Vol. 22
Issue 3
Pg. 289-96
(Jun 1981)
ISSN: 0013-9580 [Print] United States |
PMID | 7238433
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Aminobutyrates
- Excitatory Amino Acid Antagonists
- Glutamates
- Organophosphorus Compounds
- Aspartic Acid
- 2-amino-4-phosphonobutyric acid
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Topics |
- Amino Acids
(analysis)
- Aminobutyrates
(pharmacology)
- Animals
- Aspartic Acid
(antagonists & inhibitors)
- Cerebral Cortex
(analysis)
- Electroencephalography
- Epilepsy
(etiology, physiopathology)
- Excitatory Amino Acid Antagonists
- Female
- Glutamates
(physiology)
- Organophosphorus Compounds
(pharmacology)
- Rats
- Seizures
(etiology)
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