HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Lymphocyte reactivity of workers exposed to carcinogenic and non-carcinogenic chemicals.

Abstract
Immunological studies have shown an increased lymphocyte reactivity in patients with early stage bladder cancer and individuals with pre-stage T1 exposed to bladder carcinogens (2-naphthylamine and industrial 1-naphthylamine containing 4-8% 2-naphthylamine) before 1952-that is, those at high risk of developing bladder cancer. Because of the close chemical similarity of Tobias acid (2-naphthylamine-1 sulphonic acid) to 2-naphthylamine, the lymphocytotoxicity of workers exposed to this chemical was investigated. The results show that the workers using Tobias acid unlike those exposed to 2-naphthylamine have lymphocytes with a normal range of reactivity towards bladder cancer cells, which is in keeping with the suggestion that Tobias acid is non-carcinogenic. The probable reason for its non-carcinogenicity is that the relatively very large size and hydropholic properties of the sulphonic acid group prevents enzymic action on the amino group by steric hindrance. The present lymphocytotoxicity results strengthens our earlier conclusion that the observed increased lymphocyte reactivity in workers exposed to bladder carcinogens is specific.
AuthorsS Kumar, G Taylor, W Hurst, P Wilson, C B Costello
JournalBritish journal of industrial medicine (Br J Ind Med) Vol. 38 Issue 2 Pg. 167-9 (May 1981) ISSN: 0007-1072 [Print] ENGLAND
PMID7236542 (Publication Type: Journal Article)
Chemical References
  • Amines
  • Naphthalenes
  • Naphthalenesulfonates
  • 2-Naphthylamine
  • 2-naphthylamine-1-sulfonic acid
Topics
  • 2-Naphthylamine (adverse effects)
  • Aged
  • Amines (adverse effects)
  • Chemical Industry
  • Cytotoxicity, Immunologic
  • Environmental Exposure
  • Humans
  • Lymphocytes (drug effects, immunology)
  • Middle Aged
  • Naphthalenes (adverse effects)
  • Naphthalenesulfonates (adverse effects)
  • Occupational Diseases (chemically induced, immunology)
  • Urinary Bladder Neoplasms (chemically induced, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: