Additive nephrotoxicity from roentgenographic contrast media. Its occurrence in phenazopyridine-induced acute renal failure.

Abstract

A 68-year-old woman had reversible nonoliguric acute renal failure and yellow pigmentation of her skin and sclerae after ingesting phenazopyridine hydrochloride, 200 mg four times a day for six weeks. Although she began to recover renal function promptly after the drug therapy was discontinued, there was a further decline in her glomerular filtration rate after an oral cholecystogram and intravenous pyelogram. Phenazopyridine-induced acute renal failure is rare, but its early recognition is important so that additional nephrotoxicity from studies using roentgenographic contrast material may be avoided in patients with this problem.

• Authors: J E Engle, A C Schoolwerth
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 141 Issue 6 Pg. 784-6 (May 1981) ISSN: 0003-9926 [Print] United States
• PMID: 7235788 (Publication Type: Case Reports, Journal Article)

Chemical References

• Aminopyridines
• Diatrizoate
• Iopanoic Acid
• Phenazopyridine

Topics

• Acute Kidney Injury (chemically induced, diagnostic imaging)
• Aged
• Aminopyridines (adverse effects)
• Diatrizoate (adverse effects)
• Female
• Humans
• Iopanoic Acid (adverse effects)
• Kidney (drug effects)
• Phenazopyridine (administration & dosage, adverse effects)
• Radiography
• Skin Pigmentation