[Immuno-allergological study on 30 atopic patients (author's transl)].

Abstract

An immuno-allergological study was performed on 30 atopic patients and the data were compared to those of 30 healthy controls. The findings were: --increased level of IgE class immunoglobulins in the atopic patients; --increased frequency of the presence of specific reagin to numerous allergens in the sera of atopics (RAST). The total amount of IgE was related to the presence of numerous and/or strongly positive RAST; --immediate hypersensitivity reaction (IHR) to various allergens and specially house-dust. No well-definite correlation was found between IHR and RAST for the same allergens and between the in vitro determination of allergens and a known history of clinical provocation by these allergens. The frequency of positive IHR was related with high level of total IgE; --decreased frequency of delayed cutaneous hypersensitivity tests and specially of those with candidin extracts. Cutaneous hyporeactivity to natural antigens was in relation with high level of total IgE; --no significant statistical difference was found between the amount of T and B lymphocytes; --increased frequency of HLA-A2 group and decreased frequency of HLA-B7 group.

• Authors: P Amblard, J L Reymond, J Pin, G Bruttman, G Fayolle, E Volatier
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 107 Issue 11 Pg. 1007-11 ( 1980) ISSN: 0151-9638 [Print] France
• Vernacular Title: Exploration immuno-allergologique de 30 sujets atopiques.
• PMID: 7235482 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dust
• HLA Antigens
• Immunoglobulin E

Topics

• Dermatitis, Atopic (immunology)
• Dust
• HLA Antigens (analysis)
• Humans
• Hypersensitivity, Delayed (diagnosis)
• Hypersensitivity, Immediate (diagnosis)
• Immunoglobulin E (analysis)
• Leukocyte Count
• Lymphocytes (immunology)
• Skin Tests