The results of treatment with
Calmurid and
Calmurid-HC in patients with
hypertrophic scars and
keloids of various causes are reported. Histochemical and ultrastructural investigations were performed in individual cases before and
after treatment. The following results were found: 1. In the context of
keloid prophylaxis and
scar care, application of
Calmurid and
Calmurid-HC has proved very effective. The results of treating
hypertrophic scars with
urea preparations are also to be evaluated optimistically. 2. The local treatment with
Calmurid or
Calmurid-HC generally does not have a substantial influence on cosmetically disturbing
keloids. However, the skin becomes smoother, more elastic and more resistant under
Calmurid or
Calmurid-HC therapy; a reduction in the size of the
keloid mass is observed only in individual cases. 3. In short, the results are consistent with those which can be obtained with other external preparations which are specially recommended for treatment of
scars and
keloids. Success of treatment is especially dependent on the age of the lesion. 4. Disturbances in
glycosaminoglycan (GAG) and
collagen metabolism as well as
enzyme defects are the most significant factors in the pathogenesis of pathological
scars. The histochemical and electron microscopic studies reveal (of course with the necessary caution in the interpretation) that
Calmurid and
Calmurid-HC show an effect on distribution of GAG and on the
enzyme pattern of the fibroblasts. The preparations may possibly affect the disturbed processes of
collagen and GAG synthesis. The reduction of the mast cells in
keloids and
hypertrophic scars under
Calmurid treatment is noteworthy.