Treatment of Cushing's disease with bilateral adrenalectomy and autotransplantation.

Abstract

2 Cases of childhood Cushing's disease have been treated with bilateral adrenalectomy and autotransplantation of adrenal tissue. Transplantation was unsuccessful in 1 case. In the other patient, replacement therapy was discontinued without any symptoms of hypo- or hyperadrenocorticism. Her urinary 17-hydroxycorticosteroids, free cortisol and aldosterone remain in the low normal range indicating functional adrenal tissue, probably a result of the transplant.

• Authors: M D Urban, P A Lee, R K Danish, C J Migeon
• Journal: Hormone research (Horm Res) Vol. 13 Issue 2 Pg. 81-9 ( 1980) ISSN: 0301-0163 [Print] Switzerland
• PMID: 7227977 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Glucocorticoids

Topics

• Adolescent
• Adrenal Glands (transplantation)
• Adrenalectomy
• Child
• Cushing Syndrome (metabolism, surgery)
• Female
• Glucocorticoids (metabolism)
• Humans
• Transplantation, Autologous