Abstract |
In pharmacokinetic studies we proved that the efficacy of phototherapy in jaundiced Gunn rats was enhanced by administration of human albumin. The albumin injections provoked a bilirubin shift from extravascular compartments into the circulation. In this study, calculations on the optimal albumin dose were carried out. After s.c. injections a good effect could be ascertained with doses between 2 and 4 g/kg body weight. After i.v. injections effective plasma concentrations could be maintained for an acceptable time by about 2g albumin/kg body weight. When overdoses were given, a considerable amount of albumin was eliminated very quickly--especially after i.v. injections with the rapid rise of the plasma level. Clinical implications are discussed.
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Authors | G Wiese, L Ballowitz |
Journal | European journal of pediatrics
(Eur J Pediatr)
Vol. 135
Issue 3
Pg. 297-302
(Feb 1981)
ISSN: 0340-6199 [Print] Germany |
PMID | 7227385
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Albumins
(administration & dosage, therapeutic use)
- Animals
- Extracellular Space
- Hyperbilirubinemia
(therapy)
- Jaundice
(therapy)
- Phototherapy
- Rats
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