Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine.

Abstract

Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg). After 1.5 years, the 14 control and 28 treated animals were killed for general autopsy. The incidence of tumor formation in the treated animals was 78.6% as compared to 0% for the control animals. All tumors (1--3/rat) were located in the colon, with the exception of one in the Zymbal's gland of the ear and one in the small intestine. The dosage of 1,2-dimethylhydrazine used in this study is the lowest single oral dose of this carcinogen reported to induce colon tumors.

• Authors: C M Schiller, W H Curley, E E McConnell
• Journal: Cancer letters (Cancer Lett) Vol. 11 Issue 1 Pg. 75-9 (Nov 1980) ISSN: 0304-3835 [Print] Ireland
• PMID: 7226140 (Publication Type: Journal Article)

Chemical References

• Dimethylhydrazines
• Methylhydrazines

Topics

• Administration, Oral
• Animals
• Colonic Neoplasms (chemically induced)
• Dimethylhydrazines (administration & dosage)
• Dose-Response Relationship, Drug
• Male
• Methylhydrazines (administration & dosage)
• Neoplasms, Experimental (chemically induced)
• Rats