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A high level of glycosaminoglycan-synthesis of squamous cell carcinoma of the parotid gland.

Abstract
Glycosaminoglycan content of a squamous cell carcinoma derived from the parotid gland was analyzed. The tumor tissue contained a large amount of glycosaminoglycans, and the amount was strikingly larger than found in other kinds of tumor tissues (pleomorphic adenoma, scirrhous carcinoma, myxoma, etc.) analyzed previously. A culture cell line established from this tumor showed a morphologic characteristic of differentiated squamous cell carcinoma, in vitro, forming many tonofilaments in the cytoplasma and numerous desmosomes in the intercellular connection. The carcinoma cell synthesized and secreted a large amount of glycosaminoglycans, consisting mainly of hyaluronic acid. The amount of 3H-labelled hyaluronic acid secreted by this carcinoma cell was about 20-fold larger than that by HeLa cell or KB cell. Conceivably, a high level of hyaluronic acid synthesis is one of the biologic characteristics of squamous cell carcinoma derived from the duct epithelium of the salivary gland.
AuthorsJ Takeuchi, M Sobue, E Sato, M Yoshida, N Uchibori, K Miura
JournalCancer (Cancer) Vol. 47 Issue 8 Pg. 2030-5 (Apr 15 1981) ISSN: 0008-543X [Print] United States
PMID7226097 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Glycosaminoglycans
  • Hyaluronic Acid
Topics
  • Carcinoma, Squamous Cell (metabolism, pathology, ultrastructure)
  • Cell Line
  • Glycosaminoglycans (analysis, biosynthesis)
  • HeLa Cells
  • Humans
  • Hyaluronic Acid (biosynthesis)
  • Male
  • Middle Aged
  • Parotid Neoplasms (metabolism)
  • Salivary Gland Neoplasms (metabolism)

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