HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of acrylamide given during gestation on dopamine receptor binding in rat pups.

Abstract
Acrylamide (20 mg/kg) was administered by gavage to time-pregnant Fischer 344 rats daily from day 7 to day 16 of gestation. Acrylamide did not affect the number, size, or body weights of litters obtained but did decrease the [3H]spiroperidol binding in striatal membranes of 2-week-old pups. This effect could not be seen at 3 weeks of age. Scatchard analysis showed that acrylamide changed the affinity as well as the number of dopamine receptor sites. There were no signs of maternal toxicity in dosed mothers as evaluated by their body weights or general appearance.
AuthorsA K Agrawal, R E Squibb
JournalToxicology letters (Toxicol Lett) Vol. 7 Issue 3 Pg. 233-8 (Jan 1981) ISSN: 0378-4274 [Print] Netherlands
PMID7222099 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Acrylamides
  • Receptors, Dopamine
  • Spiperone
Topics
  • Acrylamides (toxicity)
  • Animals
  • Corpus Striatum (drug effects, metabolism)
  • Female
  • Gestational Age
  • Male
  • Maternal-Fetal Exchange
  • Pregnancy
  • Rats
  • Rats, Inbred F344
  • Receptors, Dopamine (drug effects, metabolism)
  • Spiperone (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: