Effects of vasopressin analogues (DDAVP, DVDAVP) in the form of sublingual tablets in central diabetes insipidus.

Abstract

The effects of 1-deamino-8-D-arginine vasopressin (DDAVP), 1-deamino-4-valin-8-D-arginine vasopressin (DVDAVP) and 8-arginine vasopressin (AVP) on water metabolism have been examined in 18 patients suffering from central diabetes insipidus. The hormone derivatives were sublingually administered. It was established that DDAVP and DVDAVP significantly reduced diuresis and increased urine osmolarity. DVDAVP was found to be more effective than DDAVP. AVP administered in equal doses had no significant effect on water metabolism. The duration of the action of sublingually administered DDAVP was 12 hrs; after dosing DVDAVP the effect lasted even 6 hrs. During one week of DDAVP administration, the accumulation of the drug was indicated by the gradual decrease of diuresis and the increase of the urine osmolarity. The sublingual administration of both DDAVP and DVDAVP tablets (3 X 30 micrograms/day) had an adequate therapeutic effect.

• Authors: F Laczi, G Mezei, J Julesz, F A Lázló
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 19 Issue 2 Pg. 63-8 (Feb 1981) ISSN: 0174-4879 [Print] Germany
• PMID: 7216552 (Publication Type: Journal Article)

Chemical References

• Tablets
• Vasopressins
• Arginine Vasopressin
• vasopressin, 1-deamino-4-Val-8-Arg-
• Deamino Arginine Vasopressin
• Valine

Topics

• Adult
• Aged
• Arginine Vasopressin (therapeutic use)
• Deamino Arginine Vasopressin (analogs & derivatives, therapeutic use)
• Diabetes Insipidus (drug therapy)
• Humans
• Male
• Middle Aged
• Mouth Floor
• Tablets
• Valine (analogs & derivatives, therapeutic use)
• Vasopressins (administration & dosage, therapeutic use)