Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.

Abstract

The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.

• Authors: E Yarkoni, E Lederer, H J Rapp
• Journal: Infection and immunity (Infect Immun) Vol. 32 Issue 1 Pg. 273-6 (Apr 1981) ISSN: 0019-9567 [Print] United States
• PMID: 7216489 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkanes
• Disaccharides
• Glycopeptides
• Acetylmuramyl-Alanyl-Isoglutamine
• Squalene
• Mineral Oil
• Trehalose
• n-hexadecane
• squalane

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (therapeutic use)
• Alkanes (therapeutic use)
• Animals
• Cell Wall (immunology)
• Disaccharides (therapeutic use)
• Female
• Freezing
• Glycopeptides (therapeutic use)
• Guinea Pigs
• Male
• Mineral Oil (therapeutic use)
• Neoplasms, Experimental (drug therapy)
• Skin Neoplasms (drug therapy)
• Squalene (analogs & derivatives, therapeutic use)
• Trehalose (therapeutic use)