[18,19,20-trinor-17-cyclohexyl-13,14-dehydro PGF 2 alpha methylester as the cause of hypertension in pulmonary circulation].

Abstract

The hemodynamic effects of a synthetic compound of PGF 2 alpha have been studied before and after vagosympathectomy. Synthetic PGF 2 alpha caused a marked hypertension in the pulmonary circulation linked with the vasoconstrictor action of this substance on the small lung vessels. A slight hypotension was observed in the denervated animal where the highest values of pulmonary pressure were reached. The authors conclude that this fact may be due to an inhibition of the vasoconstrictor systemic tone secondary to the pulmonary hypertensive state.

• Authors: O Chiara, M G Clement, A Lazzaroni, M O Triulzi
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 56 Issue 21 Pg. 2228-33 (Nov 15 1980) ISSN: 0037-8771 [Print] Italy
• Vernacular Title: Il 18,19,20-trinor-17-cicloesil-13,14-deidro PGF 2 alfa metilestere quale causa di ipertensione nel circolo polmonare.
• PMID: 7213488 (Publication Type: English Abstract, Journal Article)

Chemical References

• Prostaglandins F, Synthetic
• 18,19,20-trinor-17-cyclohexyl-13,14-dehydroprostaglandin F2alpha methyl ester
• Dinoprost

Topics

• Animals
• Dinoprost (analogs & derivatives)
• Female
• Hypertension (chemically induced)
• Male
• Prostaglandins F, Synthetic (pharmacology)
• Pulmonary Circulation (drug effects)
• Swine
• Sympathectomy
• Vagotomy