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Lisuride in parkinsonism.

Abstract
Lisuride is a soluble ergolene derivative with endocrine effects similar to but more potent than those of bromocriptine. In nine subjects with idiopathic, postencephalitic, or drug-induced parkinsonism, lisuride at a dosage of 0.05 to 0.15 mg intravenously caused an immediate improvement in tremor, rigidity, akinesia, and postural deformity, but also caused chorea and orofacial dyskinesia. Improvement lasted 2 to 3 hours. Lisuride had little or no effect in a single patient with progressively supranuclear palsy. Oral lisuride therapy, 0.8 to 4.8 mg daily, had similar effects but occasionally caused reduced awareness and hallucinations.
AuthorsJ D Parkes, M Schachter, C D Marsden, B Smith, A Wilson
JournalAnnals of neurology (Ann Neurol) Vol. 9 Issue 1 Pg. 48-52 (Jan 1981) ISSN: 0364-5134 [Print] United States
PMID7212665 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Benzimidazoles
  • Ergolines
  • Piperidines
  • Domperidone
  • Prolactin
  • Growth Hormone
  • Lisuride
Topics
  • Administration, Oral
  • Aged
  • Benzimidazoles (administration & dosage)
  • Chorea (chemically induced)
  • Domperidone
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced (etiology)
  • Ergolines (therapeutic use)
  • Female
  • Growth Hormone (blood)
  • Humans
  • Injections, Intravenous
  • Lisuride (administration & dosage, therapeutic use)
  • Male
  • Middle Aged
  • Paralysis (drug therapy)
  • Parkinson Disease (drug therapy)
  • Parkinson Disease, Postencephalitic (drug therapy)
  • Parkinson Disease, Secondary (chemically induced)
  • Piperidines (administration & dosage)
  • Prolactin (blood)

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