Effectiveness of N-N-bis-P-chlorophenyl-3p-tolyl glutaric acid diamide (SRC-3605) as a hypocholesterolaemic compound in hypercholesterolaemic female weanling and adult rats.

Abstract

SRC-3605, N-N-bis-P-chlorophenyl 3-p-tolyl glutaric acid diamide, was studied for its hypocholesterolaemic effect on serum and liver cholesterol in hypercholesterolaemic weanling and adult female rats. Weanlings were administered doses of SRC-3605 ranging from 100 to 300 mg/kg body weight for 4 or 8 consecutive days. The greatest hypocholesterolaemic effect was observed with doses of 150, 200 and 250 mg, although a progressive decreases in serum cholesterol was noted with increasing doses. Hepatic cholesterol decreases supported the serum data, but were inconsistent. Hypercholesterolaemic adult animals received 50, 100, 150 or 200 mg/kg body weight of either SRC-3605 or clofibrinic acid for 4 days. A decrease in serum cholesterol levels was observed only with the 200 mg SRC-3605. No clear-cut influence of the either compounds was found on hepatic cholesterol. The results indicated that SRC-3605 possesses the property to reduce both serum and liver cholesterol in hypocholesterolaemic weanling female rats.

• Authors: S Gujral, M Puar, N Ranka
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) 1978 Jul-Sep Vol. 22 Issue 3 Pg. 279-84 ISSN: 0019-5499 [Print] India
• PMID: 721249 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anticholesteremic Agents
• Glutarates
• N,N-bis(p-chlorophenyl)-3-(p-tolyl)glutaric acid
• Cholesterol
• Clofibrate

Topics

• Animals
• Animals, Suckling
• Anticholesteremic Agents (pharmacology)
• Cholesterol (analysis, blood)
• Clofibrate (therapeutic use)
• Female
• Glutarates (pharmacology)
• Hypercholesterolemia (drug therapy)
• Liver (analysis, drug effects)
• Rats